The winners of Manchester City s FA Cup third-round clash with Chelsea will face Premier League leaders Arsenal or Oxford United.
Top-flight champions City host Chelsea on Sunday, with Arsenal s bid for a record-extending 15th FA Cup success beginning with a visit to the League One U s on Monday.
Holders Liverpool, who overcame Chelsea on penalties in the 2022 final, will head to Brighton and Hove Albion if they can get past a replay with Wolves.
Manchester United host a Reading side managed by former midfielder Paul Ince, while Tottenham head to second-tier Preston North End.
Sheffield Wednesday s prize for stunning Newcastle United is a home draw against fellow League One side Fleetwood Town, while non-League high-flyers Wrexham welcome Sheffield United.
The draw has been made for the fourth round!
— Emirates FA Cup (@EmiratesFACup)
Elsewhere, West Ham head to third-tier Derby County, and struggling Southampton will take on Blackpool after the Seasiders dumped out Nottingham Forest.
Ties will be played on the weekend of 28 January.
FA Cup fourth-round draw in full:
Preston North End v Tottenham
Southampton v Blackpool
Wrexham v Sheffield United
Ipswich Town v Burnley
Manchester United v Reading
Luton Town or Wigan Athletic v Grimsby Town
Derby County v West Ham
Stoke City v Aston Villa or Stevenage
Blackburn Rovers v Forest Green Rovers or Birmingham City
Walsall v Leicester City
Sheffield Wednesday v Fleetwood Town
Manchester City or Chelsea v Oxford United or Arsenal
Bristol City or Swansea City v Chesterfield or West Brom
Brighton and Hove Albion v Liverpool or Wolves
Fulham v Sunderland
Boreham Wood or Accrington Stanley v Cardiff City or Leeds United